Harald Rau,Felix Cleemann,Ulrich Hersel,Silvia Kaden-Vagt,Torben Lessmann,Thomas Wegge
申请号：
US14712369
公开号：
US09457066B2
申请日:
2015.05.14
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to a prodrug or a pharmaceutically acceptable salt thereof comprising an insulin linker conjugate D-L, wherein D represents the insulin moiety； and -L is a non-biologically active linker moiety -L1 represented by formula (I),wherein the dashed line indicates the attachment to one of the amino groups of the insulin by forming an amide bond. The invention further relates to pharmaceutical compositions comprising said prodrugs as well as their use as a medicament for treating or preventing diseases or disorders which can be treated by insulin.
