WONG, Kam Wai,LAW, Yuen Kwan,EFFERTH, Thomas,XU, Su-Wei,HAMDOUN, Sami,LIU, Liang
申请号：
AU2015101808
公开号：
AU2015101808A4
申请日:
2015.12.16
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
#$%^&*AU2015101808A420160204.pdf#####ABSTRACT The present invention relates to the administration of a quinonemethide triterpenoid and its effects on subjects with multidrug-resistant cancer, in particular a cancer with enhanced expression and/or functional activity of ABC transporter proteins such as P-glycoprotein and/or an apoptosis-deficient, in particular p53-, Bax- or Bak-deficient, cancer, i.e. specific subgroups of subjects with cancer. It has been found that the quinonemethide triterpenoid is suitable to treat said cancer allowing for an accumulation of cytotoxic or therapeutic compounds in said cells while having exceptionally increased cytotoxic activity towards said multidrug-resistant cancer cells and while allowing for an increased activity of chemotherapeutic compounds. Also in accordance with the present invention is a method for specifically targeting cancer cells with multidrug-resistance as well as a method of potentiating the activity of a chemotherapeutic compound in those cancer cells. In a further aspect, a kit comprising a quinonemethide triterpenoid and a chemotherapeutic compound is provided. 46
