BUFFER SOLUTIONS HAVING SELECTIVE BACTERICIDAL ACTIVITY AGAINST GRAM NEGATIVE BACTERIA AND METHODS OF USING SAME

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专利权人:

UNITED THERAPEUTICS CORPORATION

发明人:

Roger Andrew Jeffs,David Zaccardelli

申请号：

US13912753

公开号：

US20130274340A1

申请日:

2013.06.07

申请国别(地区):

US

年份:

2013

代理人:

摘要：

Buffer solutions for pharmaceutical preparations that have bactericidal activity preferentially against gram negative bacteria are provided. The buffers have a pH of greater than about 10 or less than about 4.5 with low buffer capacity. Methods of their use in reducing the occurrence of blood stream infections in a mammal is also provided.

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