BOEHM, JEFFREY CHARLES,DAVIS, RODERICK S.,KERNS, JEFFREY,LIN, GUOLIANG,MURDOCH, ROBERT D.,NIE, HONG
申请号：
PE0000112014
公开号：
PE13852014A1
申请日:
2012.07.03
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Relates to compounds of formula (iv) where R1 is H, halogen, alkyl of C1 - 6 linear or branched, substituted phenyl, phenyl, among others R3 is H, Oh, CN, halogen, alkyl of C1 - 6 linear or branched alkyl, among others and it is a linear or branched, or C1 - 6 cycloalkyl n is an integer of 0 OR 1 5.Preferred compounds are: ({2 - [4 - [3 - (2-thienylmethyl) oxy] phenyl] methyl) - 1-piperazinyl] - 3 - piridincarboxilato 1-methylethyl 4 - [4 - (metiloxi) phenyl] amino] - 2 - [4 - (phenylmethyl) - 1 - piperazinil] - 3 - (1-methylethyl piridincarboxilato among others. These compounds are useful for the treatment of respiratory diseases or respiratory tractSE REFIERE A COMPUESTOS DE FORMULA (IV) DONDE: R1 ES H, HALOGENO, ALQUILO C1-6 LINEAL O RAMIFICADO, FENILO, FENILO SUSTITUIDO, ENTRE OTROS R3 ES H, OH, CN, HALOGENO, ALQUILO C1-6 LINEAL O RAMIFICADO, ENTRE OTROS Y ES ALQUILO C1-6 LINEAL O RAMIFICADO O CICLOALQUILO n ES 0 O UN NUMERO ENTERO DE 1 A 5. SON COMPUESTOS PREFERIDOS: 2-[4-({3-[(2-TIENILMETIL)OXI]FENIL}METIL)-1-PIPERAZINIL]-3-PIRIDINCARBOXILATO DE 1-METILETILO 4-{[4-(METILOXI)FENIL]AMINO}-2-[4-(FENILMETIL)-1-PIPERAZINIL]-3-PIRIDINCARBOXILATO DE 1-METILETILO ENTRE OTROS. DICHOS COMPUESTOS SON UTILES PARA EL TRATAMIENTO DE ENFERMEDADES RESPIRATORIAS O DEL TRACTO RESPIRATORIO
