VERHOEST, PATRICK ROBERT,ELLSWORTH, EDMUND L.,ANDERSON, JAMES THOMAS,CHERKLER, EUGENE LVOVICH PIATNITSKI,ERICKSON, BRUCE KIPP,GILBERT, ADAM MATTHEW,RICKETTS, ANTHONY P.,THOMPSON, DAVID P.,UNWALLA, RAY
申请号：
MX2015006987
公开号：
MX2015006987A
申请日:
2013.11.25
申请国别(地区):
MX
年份:
2015
代理人:
摘要：
The present invention relates to a compound of Formula 1, 2 or 3: wherein A is N or –CR0 --, where R0 is hydrogen, C1 -C6 linear or branched chain alkyl, etc., Z is –CRe --, or, –N--, where Re is hydrogen, C1 -C6 linear or branched chain alkyl,etc. R1 is hydrogen, C1 -C6 linear or branched chain alkyl, etc. R2 are independently hydrogen or C1 -C6 linear or branched chain alkyl R3 and R4 are independently hydrogen, C1 -C6 linear or branched chain alkyl, etc.. R5 and R6 are independently hydrogen or C1 -C6 linear or branched chain alkyl, etc. R8 is hydrogen, C1 -C6 linear or branched chain alkyl, etc. R9 and R10 are independently hydrogen or C1 -C6 linear or branched chain alkyl, etc. Q is --CO--, --(CH2 )q --, --(CHRS )q --, or –(CRS Rt )q--, where RS and Rt are independently C1 -C6 linear or branched chain alkyl, aryl, alkylaryl, heteroaryl or alkylheteroaryl where q is 0, 1, 2, or 3 and, where n is 0, 2, 3, 4 or 5 or, a pharmaceutically acceptable salt thereof, to compositions containing such compounds and to the uses of such compounds in the treatment of various diseases, particularly, those affected or mediated by the androgen receptor.La presente invención se refiere a un compuesto de la Fórmula 1, 2 o 3: (ver Formulas) en donde A es N o -CR0-, donde R0 es hidrógeno, alquilo de cadena lineal o ramificada de C1-C6, etc., Z es -CRe-, o, -N-, donde Re es hidrógeno, alquilo de cadena lineal o ramificada de C1-C6, etc. R1 es hidrógeno, alquilo de cadena lineal o ramificada de C1-C6, etc. R2 son independientemente hidrógeno o alquilo de cadena lineal o ramificada de C1-C6 R3 y R4 son independientemente hidrógeno, alquilo de cadena lineal o ramificada de C1-C6, etc. R5 y R6 son independientemente hidrógeno o alquilo de cadena lineal o ramificada de C1-C6, etc. R8 es hidrógeno, alquilo de cadena lineal o ramificada de C1-C6, etc. R9 y R10 son independientemente hidrógeno o alquilo de cadena lineal o ramificada de C1-C6, etc. Q es -CO-, -(CH2)q-, -(CHRs)q-, o -(C
