B型肝炎病毒(HBV)iRNA組成物及其用途方法农业专利-农业学术服务平台

发明人:: HINKLE, GREGORY,亥克尔　乔治,亥克爾　喬治,SEPP-LORENZINO, LAURA,史佩　罗瑞尼诺　拉拉,史佩　羅瑞尼諾　拉拉,JADHAV, VASANT,基哈夫　瓦圣特,基哈夫　瓦聖特,MAIER, MARTIN,马尔　马丁,馬爾　馬丁,MILSTEIN, STUART,米史坦　史特尔,米史坦　史特爾,MANOHARAN, MUTHIAH,马诺哈拉　莫司,馬諾哈拉　莫司,R,亥克尔乔治,亥克爾喬治,史佩罗瑞尼诺拉拉,史佩羅瑞尼諾拉拉,基哈夫瓦圣特,基哈夫瓦聖特,马尔马丁,馬爾馬丁,米史坦史特尔,米史坦史特爾,马诺哈拉莫司,馬諾哈拉莫司

摘要：: The present invention relates to RNAi agents, e.g., double-stranded RNAi agents, targeting the hepatitis B virus (HBV) genome, and methods of using such RNAi agents to inhibit expression of one or more HBV genes and methods of treating subjects having an HBV infection and/or HBV-associated disorder, e.g., chronic hepatitis B infection.本發明係有關靶向B型肝炎病毒(HBV)基因組之RNAi劑，例如：雙股RNAi劑，及使用此等RNAi劑抑制一或多種HBV基因表現之方法及治療患有HBV感染及/或HBV-相關病症(例如：慢性B型肝炎感染)之個體之方法。