PROBLEM TO BE SOLVED: To provide a method for monitoring the effects of treatment of chronic kidney disease and proteinuria, and diagnosis and treatment against progression.SOLUTION: According to the present invention, there is provided a method for diagnosing whether treatment for chronic kidney disease or therapy is necessary by determining whether the expression level of ROBO2 polypeptide in treatment with inhibitors such as blocking antibodies against ROBO2 polypeptide, antisense molecules, or short interfering RNAs or in a biological test sample, or the expression level of an RNA encoding the ROBO2 polypeptide exceeds a reference threshold level, based on the role of a SLIT-ROBO signaling pathway in the regulation of the podocyte F-actin cytoskeleton and pedicle structure of the kidney.SELECTED DRAWING: None【課題】慢性腎疾患およびタンパク尿症の処置、診断ならびに進行に対する処置の効果をモニターするための方法の提供。【解決手段】腎臓のポドサイトF-アクチン細胞骨格および足突起構造の調節におけるSLLIT-ROBOシグナル伝達経路の役割に基づき、ROBO2ポリペプチドに対する阻止抗体、アンチセンス分子又は短鎖干渉RNA等の阻害剤による治療や生物学的試験試料中のROBO2ポリペプチドの発現レベルまたはROBO2ポリペプチドをコードするRNAの発現レベルが、参照閾値レベルを上回るかどうかを判定して、慢性腎疾患の処置または療法の必要があるかを診断する方法。【選択図】なし
