Osintsev Aleksej Nikolaevich (RU),Осинцев Алексей Николаевич (RU)
申请号：
RU2019117613
公开号：
RU0002705572C1
申请日:
2019.06.06
申请国别(地区):
RU
年份:
2019
代理人:
摘要：
FIELD: pharmaceutics.SUBSTANCE: invention refers to pharmaceutical industry, namely to a method for preparing a concentrate of biologically active substances from antlers. Method for obtaining a concentrate of biologically active substances from antlers, according to which: skin and hair cover antlers are separated and the obtained raw material is ground to size of 1–4 mm； raw material is extracted with 70 % ethyl alcohol, acidified with acetic acid to pH 4.7–5.5, with ratio of raw material to ethyl alcohol 1÷4, while heating to temperature of 52–62 °C for 5–6 hours； after first extraction repeated extraction of 35 % ethyl alcohol, acidified with acetic acid to pH 4.7–5.5, with ratio between raw material and ethyl alcohol 1÷3, when heated to 78–80 °C for 5–6 hours； after each extraction, obtained liquid is drained and cooled； produced after extraction cake is washed from alcohol residues, is fermented in water solution with papain 0.1–0.2 % of ground raw material weight, in ratio between cake and water solution 1÷5, at temperature 36–37 °C for 7–8 hours； enzymes are inactivated in mixture at temperature 80–82 °C for 1 hour and cooling mixture to temperature of 37–39 °C； liquid hydrolyzate is separated from the mixture by filtration and separation； obtained extract and hydrolyzate are mixed, evaporated and subjected to lyophilic drying and then obtained concentrate is milled.EFFECT: concentrate obtained by the method described above is characterized by high output of biologically active substances.7 cl, 1 tblИзобретение относится к фармацевтической промышленности, а именно к способу получения концентрата биологически активных веществ из пантов. Способ получения концентрата биологически активных веществ из пантов, согласно которому: производят отделение с пантов кожного и волосяного покрова и измельчают полученное сырье до размера 1-4 мм； проводят экстракцию сырья 70%-ным этиловым спиртом, подкисленным уксусной кислотой до рН 4,7-5,5, при соотношении между сырьем и эт
