WATER-SOLUBLE DOCETAXEL ANTICANCER DRUG COMPOUND AND PREPARATION METHOD AND USE THEREOF

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专利权人:

NANJING YOUYI MEDICAL TECHNOLOGY CO.; LTD

发明人:

Yuehua Zhang

申请号：

US15762985

公开号：

US20180303949A1

申请日:

2016.01.22

申请国别(地区):

US

年份:

2018

代理人:

摘要：

The present invention discloses a water-soluble docetaxel anticancer drug compound having the structure of Formula I below:in which R=—CH3, —CH2CH3, —CH2CH2CH3, or —CH2CH2CH2CH3； and n=5-500.The active moiety docetaxel in the anticancer drug compound is covalently conjugated to a polyethylene glycol monoalkyl ether through a linker diglycoloyl (carbonyl methoxyacetyl) to form the water-soluble docetaxel anticancer drug compound.The present invention also relates to a preparation method of the drug compound and use thereof.

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