SUBSTITUTED 1,2,3-TRIAZOL-1-YL-METHYL-2,3-DIHYDRO-2-METHYL-6-NITROIMIDAZO[2,1-B]OXAZOLES AS ANTI-MYCOBACTERIAL AGENTS AND A PROCESS FOR THE PREPARATION THEREOF
The present invention relates to triazoles of new generation to contain functional 6-nitro-2, the compounds of formula I of 3-dihydroimidazooxazole reagents, their preparation method and they as drug for treating tuberculosis, MDR-TB and XDR-TB individually or with other anti-tuberculosis agents. Usually,L in formula,X is selected from a group( CH2 )Also not direct key,Wherein n is any number from 1-6,Y is selected from O,S or key,R1 is selected from H,Alkyl,Replace alkyl,Aryl,Substituted aryl,Biaryl,Substituted biaryl,Heterocycle and substituted carbocyclic ring,It includes piperazinyl that the heterocycle wherein replaced, which is selected from any one following ring,,Morpholinyl,Piperidyl,Pyridyl group,Triazolyl,Triazine radical,Pyrimidine radicals,Pyridazinyl,Oxazolyl,Furyl,Benzofuranyl,Thienyl,Pyrrole radicals,Imidazole radicals,thiazoyl,Quinolyl,Isoquinolyl,It includes F that benzooxazolyl and benzothiazolyl and above-mentioned substituted aryl and biaryl, which are selected from one group,,CI,Br,I,CF3,OCF3,OR11,NO2 and alkyl chain are from C1 to C14,Wherein R11 is selected from H,Alkyl,Phenyl and substituted phenyl.
