The present invention provides chitosan reinforced alginate beads comprising isoniazid entrapped in chitosan-alginate polyelectrolyte matrix. The present invention also provides a process for the preparation of chitosan reinforced alginate beads which involves the steps of: i) preparing an aqueous solution of sodium alginate； ii) dissolving isoniazid in distilled water to obtain a isoniazid solution； iii) adding the isoniazid solution to said solution of sodium alginate to obtain a mixture； and iv) incorporating said mixture to a calcium chloride solution containing chitosan in a drop-wise fashion to form chitosan reinforced alginate beads, followed by separating said beads, washing with distilled water, filtering and drying.
