Neelima M. Bhat,Marcia M. Bieber,Nelson N.H. Teng,Martin E. Sanders
申请号：
US12490296
公开号：
US20120237441A9
申请日:
2009.06.23
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Formulations and methods of treating human patients suffering from a condition characterized by lymphoid cancer, autoimmune disease or B cell hyperproliferation are disclosed, the treatment comprising administering (1) a cytotoxic amount of an antibody having specific binding for CDIM epitopes on a B cell, and (2) a cytotoxic agent, including a chemotherapeutic agent, radioactive isotope, cytotoxic antibody, immunoconjugate, ligand conjugate, immunosuppressant, cell growth regulator and/or inhibitor, toxin, or mixtures thereof, including agents that disrupt the cytoskeleton of B cells, particularly vinca alkaloids or colchicine.
