THE PRESENT INVENTION PROVIDES A METHOD OF TREATING A BREAST CANCER DISEASE IN A PATIENT WHO HAS FAILED PRIOR TREATMENT WITH AN ANTI-VEGF ANTIBODY, COMPRISING ADMINISTERING TO THE PATIENT A THERAPEUTICALLY EFFECTIVE AMOUNT OF AN ANTI-HER2 ANTIBODY WHILE CONTINUING SAID ANTI-VEGF ANTIBODY THERAPY. THE INVENTION ALSO PROVIDES CORRESPONDING ARTICLES OF MANUFACTURE AND PHARMACEUTICAL COMPOSITIONS. MOST ILLUSTRATIVE FIGURE 1