Peter Alistair ROBBINS,Gus HANCOCK,Grant RITCHIE,James MOUNTAIN,David O'NEILL,Jonathan WHITELEY,Luca CIAFFONI,John COUPER
申请号：
US16328773
公开号：
US20190223761A1
申请日:
2017.08.15
申请国别(地区):
US
年份:
2019
代理人:
摘要：
A method and apparatus for non-invasive assessment of lung inhomogeneity by accurate high temporal resolution measurement of respiratory gas flows at the mouth during steady state breathing and inert gas wash-in or wash-out and using these measurements to fit a mathematical model of the inhomogeneous lung. The model of the lung is based on modelling the lung as plural alveolar compartments each having an identical volume at functional residual capacity, but varying in its fractional share of total lung compliance, total pulmonary vascular conductance and total anatomical deadspace. A bivariate log-normal distribution of the lung compliance and pulmonary vascular conductance is used, together with a normal distribution of deadspace fraction. The model is fitted to the measurements using non-linear regression and the distribution of ventilation: perfusion ratios, lung compliance: volume ratios, lung vascular conductance: volume ratios and lung deadspace: volume ratios obtained from the fitted model are indicative of the airway condition and thus lung function of the subject.
