PASHINE, Achal,GOSSELIN, Michael L.,YAMNIUK, Aaron P.,HOLMES, Derek A.,CHEN, Guodong,MADIA, Priyanka Apurva,HUANG, Richard Yu-Cheng,CARL, Stephen Michael
申请号：
AU2019248547
公开号：
AU2019248547A1
申请日:
2019.04.01
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling, wherein the antibodies do not bind to one or more FcRs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.
