Achal Pashine,Michael L. Gosselin,Aaron P. Yamniuk,Derek A. Holmes,Guodong Chen,Priyanka Apurva Madia
申请号：
US16371964
公开号：
US20190300608A1
申请日:
2019.04.01
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling, wherein the antibodies do not bind to one or more FcγRs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.
