PURPOSE: A complex cultivating method of Chaga mushroom, Phellinus baumii, Ganoderma lucidum, Blossom mushroom, and Cordyceps is provided to mass-produce the complex culture mycelia of blossom mushroom, Ganoderma lucidum, and Cordyceps and is provided for medical supplies and functional foods such as anticancer. CONSTITUTION: A step(first process) of finely comminuting after drying more than one kind of mushrooms selected from Shiitake mushroom, Blossom mushroom, and Agaricus mushroom； a step(second process) of manufacturing medium by controlling the moisture of the mushroom powder which is selected from one kind of mushroom from Shiitake mushroom, Blossom mushroom, and Agaricus mushroom to 20-60% and sterilizing； and a step(third process) of cultivating by engrafting medium containing more than one kind of mushroom selected from Shiitake mushroom, Blossom mushroom, and Agaricus mushroom manufactured in second process by respectively aseptic processing Chaga mushroom, Phellinus baumii, Ganoderma lucidum, Blossom mushroom, and Cordyceps at 20-40°；C for 15-50 days is comprised. In the third process, inoculate Chaga mushroom, Phellinus baumii, Ganoderma lucidum, Blossom mushroom, and Cordyceps respectively by 0.1-1 parts by weight to medium 100 parts by weight containing more than one kind of mushroom selected from Shiitake mushroom, Blossom mushroom, and Agaricus mushroom. In the third process, instead of inoculating to the medium which contains more than one kind of mushroom selected from Chaga mushroom, Phellinus baumii, Ganoderma lucidum, Blossom mushroom, and Cordyceps, inoculate complex culture mycelia of these 5 kinds of mushrooms to the medium which contains more than one kind of mushroom selected from Shiitake mushroom, Blossom mushroom, and Agaricus mushroom. Inoculate 0.5-5 parts by weight of complex culture mycelia with the five kinds of mushrooms to the medium containing more than one kind of mushroom selected from Shiitake mushroom, Blossom mushroom, a
