Chemical reagents for the activation of polysaccharides in the manufacture of conjugate vaccines

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专利权人:

フィナ バイオソリューションズ リミテッド ライアビリティ カンパニー

发明人:

リース アンドリュー

申请号：

JP2012544919

公开号：

JP5892944B2

申请日:

2010.12.17

申请国别(地区):

JP

年份:

2016

代理人:

摘要：

This invention provides novel reagents for cyanating polysaccharides in aqueous or part aqueous solutions so that they may be covalently linked to proteins either directly or through a spacer. These reagents include 1-cyano-4-pyrrolidinopyridinium tetrafluoroborate (CPPT), 1-cyano-imidazole (1-CI), 1-cyanobenzotriazole (1-CBT), or 2-cyanopyridazine-3(2H)one (2-CPO), or a functional derivative or modification thereof. The examples illustrate the use of these reagents with a variety of polysaccharides and proteins showing that the methods are generally applicable.

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