Provided is a compound having an excellent integrin [alpha]4 inhibiting action. A sulfonamide derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof. (In the formula, R1-R5, e-h, D, and B are as defined in the specification.).本發明為提供一種具有優異之α4整合蛋白抑制作用之化合物。其係提供一種下述一般式(I)所表示之磺胺衍生物或其醫藥上所容許之鹽,(式中,R1~R5、e~h、D以及B如說明書中之記載所述)。