Lornoxicam is a non steroidal anti-inflammatory drug with analgesic properties and belongs to the class oxicams having extremely bitter taste. So the taste has to be masked in order to reduce its bitterness to increase its palatability and to improve patient compliance. The purpose of this research work is to prepare tasteless complexes of Lornoxicam with Kyron a cationic ion - exchange resin to evaluate bitterness and invitro drug release from the Drug- Resin complex (DRC). Here DRC was prepared by Batch method using Kyron T – 104 Kyron T- 114 Kyron T- 314 carbopol 934 P and instamask. It was found that percentage of drug bound to resin was more with Kyron T -114 and selected it for preparing DRC using ratios from 1:1 to 1:4 and it was founded that 1:3 as the optimized one.
