Famotidine [(N"-(Aminosulfonyl)-3-(((2-((diaminomethylene) amino)-4thiazolyl) methyl) thio) propanimidamide] an H2 histamine receptor antagonist has extremely bitter taste. Its bitter taste became a critical issue which strongly demanded to mask the taste. Different types of ion exchange resins like Kyron T-104 Kyron T-114 Kyron T-314 instamask and Carbopol 934 P were used in different proportions to form complex with famotidine. Ion exchange resin to drug ratio effect of pH and effect of stirring time on complex formation were optimized. Drug-resin complex was evaluated for percent drug loading and drug release from drug-resin complex. Developed taste masked drug candidate in this research work become eligible to formulate mouth disintegrating dosage form.
