Krueger, Allan C.,Gao, Yi,Kotecki, Brian J.,Flentge, Charles A.,Motter, Christopher E.,Maring, Clarence J.,Liu, Dachun,Betebenner, David A.,Degoey, David A.,Barnes, David M.,Hutchinson, Douglas K.,Zha
申请号：
AU2013202002
公开号：
AU2013202002A1
申请日:
2013.03.26
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
#$%^&*AU2013202002A120130418.pdf#####URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C ABSTRACT Present application relates to the compounds of formula I useful to treat hepatitis C (HCV) infections. In the structure of the disclosed compounds is the uracil or thymine derivative linked via a phenylene into either fused 2-ring cyclic system (R6) or alternatively via additional twoatom linker (L) to a 5-6 membered monocycle (R6). Application further discloses polymorphs and pseudopolymorphs of two specific compounds: N-(6(3-t-butyl-5-(2>4-dioxo-3,4dihydropyrimidin-1 (2H)- y!)2-methoxy-phenyl)naphthalen-2-yl)methanesulfonamide and (E)N-(4(3-t-butyl-5-(2,4-dioxo-3)4-dihydropyrimidin-1(2H)-yl)2-methoxy-styrylphenyl)methanesulfonamide.
