Henry, Rodger F.,Donner, Pamela L.,Lou, Xiaochun,Kotecki, Brian J.,Barnes, David M.,Maring, Clarence J.,Betebenner, David A.,Longenecker, Kenton L.,Flentge, Charles A.,Liu, Dachun,Pratt, John K.,Zhang
申请号：
AU2008302448
公开号：
AU2008302448B2
申请日:
2008.09.17
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
Present application relates to the compounds of formula I useful to treat hepatitisC (HCV) infections. In the structure of the disclosed compounds is the uracilor thymine derivative linked via a phenylene into either fused 2-ring cyclicsystem (R6) or alternatively via additional two-atom linker (L) to a 5-6 memberedmonocycle (R6). Application further discloses polymorphs and pseudopolymorphsof two specific compounds: N-(6(3-t-butyl-5-(2>；4-dioxo-3,4-dihydropyrimidin-1(2H)- y!)2-methoxy-phenyl)naphthalen-2-yl)methanesulfonamide and (E)-N-(4(3-t-butyl-5-(2,4-dioxo-3)4-dihydropyrimidin-1 (2H)-yl)2-methoxy-styryl-phenyl)methanesulfonamide.
