The disclosure provides chimeric antigen receptors (CARs), T cells comprising such CARs, nucleic acids that encode such CARS, and methods of use thereof, e.g., to treat cancer such as B cell malignancies.本發明係提供嵌合抗原受體(chimeric antigen receptors;CARs)、含此類CARs之T細胞、編碼此類CARs之核酸、及使用其之方法,例如,用於治療癌症如B細胞惡性腫瘤。