A packaged kit for performing a photodynamic laser myringotomy includes a pluralityof ear needles having different shaped absorbent applicators on distal endsof the needles, a vial of a single dose of an otologic formulation of mitomycin-C,a diluent carrier containing sterilized water, and a syringe. The componentparts of the kit are used together to reconstitute the contents of the vial withthe water in the diluent carrier, and then draw the reconstituted drug into thesyringe. A selected one of the plurality of ear needles is then communicated withthe syringe. The syringe and needle are then used to inject the reconstituteddrug into the absorbent pad at the end of the needle, and the absorbent pad containingthe drug is used to apply the drug to the tympanic membrane. The application ofthe drug to the tympanic membrane prepares the membrane for a myringotomy procedure,and in particular, a photodynamic laser myringotomy.