PH SENSITIVE CARRIER AND METHOD FOR PRODUCTION THEREOF PH SENSITIVE MEDICINE AND PH SENSITIVE PHARMACEUTICAL COMPOSITION EACH CONTAINING SAID CARRIER AND CULTURE METHOD USING SAID PH SENSITIVE MEDICINE OR SAID PH SENSITIVE PHARMACEUTICAL COMPOSITION
Provided are: a pH sensitive carrier which can be used as a carrier for a physiologically active substance and can respond to a weakly acidic environment to exhibit an effect of promoting a membrane disrupting function； a method for producing the pH sensitive carrier； a pH sensitive medicine and a pH sensitive pharmaceutical composition each of which contains the carrier； and a culture method using the pH sensitive medicine or the pH sensitive pharmaceutical composition. A pH sensitive carrier which can exhibit an effect of promoting a membrane disrupting function said pH sensitive carrier comprising: at least one pH sensitive compound selected from the group consisting of deoxycholic acid cholic acid ursodeoxycholic acid chenodeoxycholic acid hyodeoxycholic acid a higher bile acid glycodeoxycholic acid glycyrrhizic acid glycyrrhetinic acid and salts thereof； and at least one amphipathic substance selected from the group consisting of a phosphatidylcholine having 10 to 12 carbon atoms a polyoxyethylene sorbitan mono fatty acid ester having 12 to 18 carbon atoms a sorbitan fatty acid ester having 16 to 18 carbon atoms glycerol monooleate glycerol dilaurate glycerol distearate glycerol dioleate polyoxyethylene castor oil and a tocopherol.
