A hand-held aspiration apparatus includes a handle configured for suspending and using the syringe with a single hand. The handle includes pivotally connected first and second members. The members of the handle may be pivotally connected at intermediate positions along the lengths thereof. The first member is associated with, and may be pivotally connected to, a syringe barrel, while the second member is associated with, and may be pivotally connected to, a syringe plunger. The members are configured and associated with one another in such a way that movement of portions thereof toward each other moves the plunger proximally through the barrel, which may create a vacuum in the barrel that may facilitate aspiration, and that movement of portions of the members away from one another moves the plunger distally through the barrel. The aspiration apparatus may be configured for a single-use (i.e., it may be disposable). Applications of use and methods of using a hand-held syringe are also disclosed.