A syringe comprises a barrel portion (20) and a plunger portion (30) comprising a distal end adapted for insertion into a proximal end of the barrel portion (20). A gripping device (160) is positioned on a proximal end (31) of the plunger portion. The gripping device comprises an open loop portion that is sized and configured to operatively receive a users thumb and to facilitate one-handed aspiration during operation of the syringe.