A wire guide has first and second portions with first and second diameters, respectively. The second portion is located distal of the first portion. A resilient loop positions a distal end of the wire guide adjacent another section of the wire guide. A closure member maintains the distal end in a fixed position relative to the remainder of the wire guide. An outer sleeve may be positioned around one or more parts of the wire guide. A radiopaque element may be secured to the outer sleeve.