A wire guide (10) has first (14) and second (18) portions with first (16) and second (20) diameters, respectively. The second portion is located distal of the first portion. A resilient loop (22) positions a distal end of the wire guide adjacent another section of the wire guide. A closure member maintains the distal end in a fixed position relative to the remainder of the wire guide. An outer sleeve (80, 90) may be positioned around one or more parts of the wire guide. A radiopaque element may be secured to the outer sleeve.