Arizona Board of Regents on Behalf of the University of Arizona
发明人:
Minkyu Kim,Christopher P. Camp
申请号：
US16253825
公开号：
US20190224362A1
申请日:
2019.01.22
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Biopolymer compositions comprising antimicrobial peptides (AMPs) for treating infections such as bacterial infections, viral infections, fungal infections, and parasitic infections. The compositions herein may also be used for treating infections associated with antibiotic-resistant bacteria, antifungal-resistant fungi, antiviral-resistant viruses, or for treating biological warfare agents (BWAs) such as Bacillus anthracis and Yersenia pestis. The present invention also provides methods of synthesis of said biopolymer compositions, wherein AMP biopolymers can be synthesized as an artificially engineered protein by genetically fusing an AMP； a protein that behaves similarly to polymer tethers； and a protein as a modifiable material platform that can transform to self-assembled nanoparticles, self-standing films, or adhesives to easily attach tethered AMPs onto any biomaterial surface for various clinical applications.
