Prapasri Sinswat;Keith P. Johnston;Robert O. Williams;Jay I. Peters;Robert Talbert;True L. Rogers;Alan B. Watts;Jason T. McConville
发明人:
Robert O. Williams,Keith P. Johnston,Prapasri Sinswat,Jason T. McConville,Robert Talbert,Jay I. Peters,Alan B. Watts,True L. Rogers
申请号：
US12522774
公开号：
US09044391B2
申请日:
2008.01.10
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention includes compositions and methods for making and using a rapid dissolving, high potency, substantially amorphous nanostructured aggregate for pulmonary delivery of tacrolimus and a stabilizer matrix comprising, optionally, a polymeric or non-polymeric surfactant, a polymeric or non-polymeric saccharide or both, wherein the aggregate comprises a surface area greater than 5 m2/g as measured by BET analysis and exhibiting supersaturation for at least 0.5 hours when 11-15-times the aqueous crystalline solubility of tacrolimus is added to simulated lung fluid.
