Robert O. WILLIAMS, III,Keith P. JOHNSTON,Prapasri SINSWAT,Jason T. MCCONVILLE,Robert TALBERT,Jay I. PETERS,Alan B. WATTS,True L. ROGERS
申请号：
US16294885
公开号：
US20190269661A1
申请日:
2019.03.06
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention includes compositions and methods for making and using a rapid dissolving, high potency, substantially amorphous nanostructured aggregate for pulmonary delivery of tacrolimus and a stabilizer matrix comprising, optionally, a polymeric or non-polymeric surfactant, a polymeric or non-polymeric saccharide or both, wherein the aggregate comprises a surface area greater than 5 m2/g as measured by BET analysis and exhibiting supersaturation for at least 0.5 hours when 11-15-times the aqueous crystalline solubility of tacrolimus is added to simulated lung fluid.
