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CATALYTIC RADIOFLUORINATION
专利权人:
THE GENERAL HOSPITAL CORPORATION
发明人:
ELMALEH, DAVID,SHOUP, TIMOTHY,FISCHMAN, ALAN
申请号:
HK12105036.1
公开号:
HK1164148B
申请日:
2012.05.23
申请国别(地区):
HK
年份:
2015
代理人:
摘要:
One aspect of the present invention relates to a method of preparing radiofluorinated substituted alkyl, cycloalkyl, aryl, and alkenyl compounds. In a preferred embodiment, potassium fluoride-18 is used. Another aspect of the invention relates to piperazine compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the piperazine compounds contain a quaternary amine. Another aspect of the invention relates to arylphosphonium compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the phosphonium compound is a tetraaryl phosphonium sait. Another aspect of the present invention relates to a method of obtaining a positron emission image of a mammal, comprising the steps of administering to a mammal a compound of the invention, and acquiring a positron emission spectrum of the mammal.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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