Fischman, Alan J.,Shoup, Timothy M.,Shoup, Timothy M.
申请号：
AU2012205161
公开号：
AU2012205161A1
申请日:
2012.07.06
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2012205161A120120802.pdf#####Catalytic Radiofluorination Abstract One aspect of the present invention relates to a method of preparing radiofluorinated substituted alkyl, cycloalkyl, aryl, and alkenyl compounds. In a preferred embodiment, 5 potassium fluoride-18 is used. Another aspect of the invention relates to piperazine compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the piperazine compounds contain a quarternary amine. Another aspect of the invention relates to arylphosphonium compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the phosphonium compound is a to tetraaryl phosphonium salt. Another aspect of the present invention relates to a method of obtaining a positron emission image of a mammal, comprising the steps of administering to a mammal a compound of the invention, and acquiring a positron emission spectrum of the mammal.
