The present invention discloses a preparation method for toothpaste composition containing ganoderma lucidum component, wherein the ganoderma lucidum component is sporoderm-broken ganoderma lucidum spore, it comprises the following steps: (1) dissolve water, sorbitol, PEG-8, propylene glycol, sodium saccharine, sodium benzoate and the extract of opuntia in a toothpaste-making pot； (2) premix calcium hydrogen phosphate, hydrated silica, sodium lauryl sulfate, cellulose gum, hydroxyethyl cellulose, sporoderm-broken ganoderma lucidum spore, Panax notoginseng powder, and radix scutellariae root powder in powder tank evenly to form a mixture； (3) stir the mixture obtained in step (2) under vacuum and inhale into the toothpaste-making pot of step (1)； control the vacuum degree at minus 0.098 to minus 0.1 Mpa and stir for 15 minutes； (4) inhale the essence into the toothpaste-making pot, stir for 10 minutes, and discharge. The preparation method of the present invention is of simple technique, easy operation, and high efficiency and the obtained toothpaste composition containing ganoderma lucidum component has good using effect.
