As for the endoscope, one end is locked by the grip section and directing the cover component and the cover component which are installed on the side which is approached to the inner grip section of the manipulation knob and the manipulation knob where the other end the 1st axis which outside the grip section extending is put out and, is laid out in the 1st axis and on the same axis around the axis of the 1st axis rotary possibility the biaxial and the biaxial around that axis revolution operational is installed to the manipulation knob, the pushing with the pushing pressure component and the pushing pressure component which it overpowers on the side which approaches the supporter and the manipulation knob which it supports to the grip section in the manipulation knobDirecting, as, the pushing the 1st seal component and the pushing pressure component and the manipulation knob of the ring condition which is overpowered it is formed at least and on the one hand it inclines axial direction of the 1st axis and vis-a-vis the direction which crosses in axial direction of the 1st axis and directing to the manipulation knob with the pushing pressure component, the pushing it supports the 1st seal component which is overpowered in a state where it is circumscribed to the 1st axis the 1st seal component it possesses with the slant face which is supported in the direction which parallels to the axial direction of the 1st axis.内視鏡は、把持部に一端が固定され他端が把持部の外側に延出された第1軸と、第1軸と同軸上に配置され第1軸の軸回りに回転可能な第2軸と、第2軸をその軸回りに回転操作可能に取り付けられた操作ノブと、操作ノブのうち把持部に近接する側に取り付けられる蓋部材と、蓋部材を操作ノブに向けて支持する支持部と、操作ノブを把持部に近接する側に押圧する押圧部材と、押圧部材により操作ノブに向けて押圧されたリング状の第1シール部材と、押圧部材及び操作ノブの少なくとも一方に形成され第1軸の軸方向及び第1軸の軸方向に直交する方向に対して傾斜し押圧部材により操作ノブに向けて押圧された第1シール部材を第1軸に外接した状態に支持するとともに第1シール部材を第1軸の軸方向に沿った方向に支持する斜面とを有する。