SATO SEIJI,HANADA TAKESHI,WAKABAYASHI NAOMI,MASUDA YUTAKA,HARADA YURIKO
申请号：
ZA201200440
公开号：
ZA201200440B
申请日:
2012.01.19
申请国别(地区):
ZA
年份:
2013
代理人:
摘要：
The present invention aims at providing motilin-like peptide compounds that maintain the gastrointestinal motility stimulating activity of native motilin and which are adapted to have higher absorbability upon transmucosal administration. Motilin derivatives were designed and synthesized in consideration of the pathway for the degradation of motilin at a site of its transmucosal absorption and the maintenance of motilin's physiological activity and compounds characterized by substitutions for the amino acid at position 21 of native motilin have been found to show higher absorbability upon transmucosal administration and yet maintain the same activity as motilin.
