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MOTILIN-LIKE PEPTIDE COMPOUND HAVING TRANSMUCOSAL ABSORBABILITY IMPARTED THERETO
专利权人:
DAIICHI SANKYO COMPANY; LIMITED
发明人:
SATO, SEIJI,HANADA, TAKESHI,WAKABAYASHI, NAOMI,MASUDA, YUTAKA,HARADA, YURIKO
申请号:
MYPI 2012000392
公开号:
MY161842A
申请日:
2010.07.29
申请国别(地区):
MY
年份:
2017
代理人:
摘要:
THE PRESENT INVENTION AIMS AT PROVIDING MOTILIN-LIKE PEPTIDE COMPOUNDS THAT MAINTAIN THE GASTROINTESTINAL MOTILITY STIMULATING ACTIVITY OF NATIVE MOTILIN AND WHICH ARE ADAPTED TO HAVE HIGHER ABSORBABILITY UPON TRANSMUCOSAL ADMINISTRATION. MOTILIN DERIVATIVES WERE DESIGNED AND SYNTHESIZED IN CONSIDERATION OF THE PATHWAY FOR THE DEGRADATION OF MOTILIN AT A SITE OF ITS TRANSMUCOSAL ABSORPTION AND THE MAINTENANCE OF MOTILIN’S PHYSIOLOGICAL ACTIVITY AND COMPOUNDS CHARACTERIZED BY SUBSTITUTIONS FOR THE AMINO ACID AT POSITION 21 OF NATIVE MOTILIN HAVE BEEN FOUND TO SHOW HIGHER ABSORBABILITY UPON TRANSMUCOSAL ADMINISTRATION AND YET MAINTAIN THE SAME ACTIVITY AS MOTILIN.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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