A microscope system is characterized in comprising a transmission illumination optical system having a light source (11) and a condenser lens (13); a first dry objective (15a) having a magnification of from 20 or higher to 40 or lower and capable of viewing by at least one of a differential interference viewing method and a modulation contrast viewing method; and a second dry objective (15b) having a magnification of from 60 or higher to 100 or lower and capable of viewing by a differential interference viewing method; the first objective (15a) and the second objective (15b) being exchangeable.