Substituted pyrrolo[1,2-A] pyrazines, compositions containing these, processes of making these, and uses thereof

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专利权人:

Marisa Martinelli;Carla Ghelardini;Carlo Parini;Silvano Ronzoni

发明人:

Carla Ghelardini,Marisa Martinelli,Carlo Parini,Silvano Ronzoni

申请号：

US12918718

公开号：

US08334286B2

申请日:

2009.02.17

申请国别(地区):

US

年份:

2012

代理人:

摘要：

The invention refers to compounds of general formula (I) wherein the R groups are, independently, H, C1-6alkyl, aryl, CF3； Y is CH2, C═O； X is bond, C═O, SO2, or C═N—CN； m is 0, 1； n is 0, 1； A is a heterocycle, or a phenyl group optionally substituted as defined in the specification. The compounds are active on chronic pain conditions of different origin； they can be administered alone or with other drugs. Most of these compounds are new. The invention include a process to prepare said compounds, and pharmaceutical compositions suitable for their administration to a patient.

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