Disclosed are a patch, system, and method for delivery of a permeantcomposition into a subject via at least oneformed pathway through a biological membrane of the subject. The patchcomprises a matrix, at least one hydrophilic permeantdisposed within the matrix, wherein at least a portion of the permeant candissolve in biological moisture received from thesubject, and at least one permeability enhancer disposed within the matrix.Also disclosed are systems and methods for delivery of apermeant composition into a subject via at least one formed pathway through askin layer of the subject.