A device for the fixation and support of vertebral bodies includes a base member for implantation into a patient at a location between two vertebral bodies. The base member (20) of the device includes an enclosed chamber (192) for receiving fusion material and apertures (140,180) for receiving bone fasteners that can be embedded into the adjacent bone bodies. The device further includes protrusions (30) extending from the base member, wherein the protrusions are configured for engagement with one or more bone bodes upon implantation and for progressive penetration into at least one bone body over a period of time subsequent to the implantation.