Adam S. Cantor;Jacqueline M. Ganser;Michael W. Mueting;Stephen W. Stein
发明人:
Adam S. Cantor,Jacqueline M. Ganser,Michael W. Mueting,Stephen W. Stein
申请号：
US12995319
公开号：
US09956170B2
申请日:
2009.06.22
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A method of making a dry powder pharmaceutical composition comprising: providing inactive ingredient particles； providing a micronized active ingredient； mixing the inactive ingredient particles with surface-modified nanoparticles to provide an inactive ingredient comprised of particles having surfaces with the surface-modified nanoparticles deposited on the surfaces； and/or mixing the micronized active ingredient with surface-modified nanoparticles to provide a micronized active ingredient comprised of particles having surfaces with the surface-modified nanoparticles deposited on the surfaces； and then mixing the micronized active ingredient with the inactive ingredient； the dry powder compositions made by the method； a use of said composition for the manufacture of a medicament for being delivered to the lungs of a mammal by administering a therapeutic amount of the dry powder pharmaceutical composition, and a dry powder inhalation device comprising a mouth piece, a powder containment system, and the dry powder pharmaceutical composition are disclosed.
