Novel pyrimidine derivatives of formula (I) and their use for the manufacture of a medicament for the treatment or prevention of a disease which responds to inhibition of FAK and/or ALK and/or ZAP-70 and/or IGF-IR. in which: n is selected from 1,2 and 3 R 1 is selected from phenyl, pyridinyl, pyrazolyl and pyrimidinyl and R 2 and R 3 are as described herein.