Chen, Jinsheng,Wilson, Kenneth,Wall, Mark,Meegalla, Sanath K.,Illig, Carl R.,Ballentine, Shelley K.,Desjarlais, Renee Louise,Tomczuk, Bruce E.
申请号：
AU2007240440
公开号：
AU2007240440B2
申请日:
2007.04.18
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The invention is directed to compounds of Formula I: wherein Z, X, J, Rand W are set forth in the specification, as well as solvates, hydrates, tautomersand pharmaceutically acceptable salts thereof, that inhibit protein tyrosinekinases, especially c-fms kinase. Methods of treating autoimmune diseases；and diseases with an inflammatory component； treating metastasis from ovariancancer, uterine cancer, breast cancer, prostate cancer, lung cancer, coloncancer, stomach cancer, hairy cell leukemia； and treating pain, including skeletalpain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory,and neurogenic pain； as well as osteoporosis, Paget's disease, and otherdiseases in which bone resorption mediates morbidity including rheumatoidarthritis, and other forms of inflammatory arthritis, osteoarthritis, prosthesisfailure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with thecompounds of Formula I, are also provided.
