University of South Alabama Foundation for Research and Commercialization
发明人:
Richard Eric Honkanen,Brandon Marshall D'Arcy,Mark Raymond Swingle
申请号：
US16672185
公开号：
US20200179452A1
申请日:
2019.11.01
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Compositions, methods, and systems for modifying sterol metabolism in a subject is disclosed. In some embodiments, the subjects may be administered one or more mammalian cells modified to express at least one sterol degrading enzyme derived from a bacterium. In many embodiments, the cell is a macrophage or monocyte stably expressing three or more enzymes that aid in opening the β ring of cholesterol. The disclosed compositions and methods may be useful in lowering cholesterol levels in a subject in need thereof. In some embodiments, the subject may have a genetic predisposition to atherosclerosis.
