FRED HUTCHINSON CANCER RESEARCH CENTER;SEATLE CHILDREN'S HOSPITAL D/B/A SEATTLE CHILDREN'S RESEARCH INSTITUTE
发明人:
Colleen Delaney,Michael Jensen,Rebecca Gardner
申请号：
US16445053
公开号：
US20190381104A1
申请日:
2019.06.18
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Hematopoietic stem/progenitor cells (HSPC) and/or non-T effector cells are genetically modified to express (i) an extracellular component including a ligand binding domain that binds a cellular marker preferentially expressed on an unwanted cell； and (ii) an intracellular component comprising an effector domain. Among other uses, the modified cells can be administered to patients to target unwanted cancer cells without the need for immunological matching before administration.
