FRED HUTCHINSON CANCER RESEARCH CENTER;SEATTLE CHILDREN'S HOSPITAL, D/B/A SEATTLE CHILDREN'S RESEARCH INSTITUTE
发明人:
DELANEY, COLLEEN,JENSEN, MICHAEL,GARDNER, REBECCA
申请号：
CA2929087
公开号：
CA2929087A1
申请日:
2014.10.31
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Hematopoeitic stem/progenitor cells (HSPC) and/or non-T effector cells are genetically modified to express (i) an extracellular component including a ligand binding domain that binds a cellular marker preferentially expressed on an unwanted cell； and (ii) an intracellular component comprising an effector domain. Among other uses, the modified cells can be administered to patients to target unwanted cancer cells without the need for immunological matching before administration.
