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ANTICORPS ARTIFICIEL PRODUIT À L'AIDE D'UNE SÉQUENCE PARTIELLE DE PROTÉINE ÉNOLASE ISSUE DE PLASMODIUM FALCIPARUM, ET SON PROCÉDÉ DE PRODUCTION
专利权人:
JAPAN AGENCY FOR MEDICAL RESEARCH AND DEVELOPMENT
发明人:
申请号:
EP15862466.8
公开号:
EP3225629A4
申请日:
2015.11.27
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
The present invention provides a bioactive peptide including a partial amino acid sequence of Plasmodium falciparum enolase, and having a molecular structure compatible with a specification setting for a GMP-compliant production process. Provided is a peptide having a structure in which two peptides each having (i) an amino acid sequence represented by: A01-Ala-Ser-Glu-Phe-Tyr-Asn-Ser-Glu-Asn-Lys-Thr-Tyr-Asp-Leu-Asp-Phe-Lys-Thr-Pro-Asn-Asn-Asp-A02 (SEQ ID NO: 1) or (ii) an amino acid sequence represented by: A03-Ala-Ser-Glu-Phe-Tyr-Asn-Ser-Glu-Asn-Lys-Thr-Tyr-Asp-Leu-Asp-Phe-Lys-Thr-Pro-Asn-Asn-Asp-Lys-Ser-Leu-Val-Lys-Thr-A04 (SEQ ID NO: 2) are linked by amide bonds between the respective carboxy termini of the two peptides and two amino groups of Lys in a linker peptide represented by (iii): Lys-A05-Cys-A06 and arranged in the form of a two-forked branch. Preferred is a peptide having a dimerized structure in which two of the above described peptides are linked by an S-S bond between the Cys residues in the linker peptide sequences included in the respective two peptides. (In the above (i), (ii), and (iii), A01 to A06 each represents an amino acid residue in a number of an arbitrary number including 0).
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